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BOTOX® for Hyperhidrosis :: Publications
BOTOX® has been approved for use in patients with hyperhidrosis in Canada (2001). Although commonly used, it is not yet approved in the US for this purpose. There are many publications describing the use of BOTOX® in hyperhidrosis and in addition, there are many ongoing clinical trials.
The landmark trial demonstrating the utility of BOTOX® for the treatment of hyperhidrosis can be found in the following reference:
- Naumann M, Lowe NJ. Botulinum toxin type A in treatment of bilateral primary axillary hyperhidrosis: randomised, parallel group, double blind, placebo controlled trial.BMJ. 2001 Sep 15;323(7313):596-9.
We will update the reference information as more information becomes available.
References for more information include:
- Fujita M, Mann T, Mann O, Berg D. Surgical pearl: use of nerve blocks for botulinum toxin treatment of palmar-plantar hyperhidrosis. J Am Acad Dermatol 2001 Oct;45(4):587-9
- de Almeida AR, Kadunc BV, de Oliveira EM. Improving botulinum toxin therapy for palmar hyperhidrosis: wrist block and technical considerations. Dermatol Surg. 2001 Jan;27(1):34-6.
- Heckmann M, Ceballos-Baumann AO, Plewig G: Botulinum toxin A for axillary hyperhidrosis (excessive sweating). N Engl J Med 344:488, 2001.
- Carruthers A, Carruthers J. Toxins 99. New information about the botulinum neurotoxins. Dermatol Surg 2000;26:174–6.
- Naumann M, Hamm H, Kinkelin I, Reiners K. Botulinum toxin type A in the treatment of focal, axillary and palmar hyperhidrosis and other hyperhidrotic conditions. Eur J Neurol 1999; 6(suppl.4): S111-S115.
- Heckmann M, Breit S, Ceballos-Baumann A, Schaller M, Plewig G. Side-controlled intradermal injection of botulinum toxin type A in recalcitrant axillary hyperhidrosis. J Am Acad Dermatol 1999; 41: 987-990
- Schnider P, Binder M, Kittler H, Birner P, Starkel D, Wolff K, et al. A randomized, double-blind, placebo-controlled study trial of botulinum toxin type A for severe hyperhidrosis. Br J Dermatol 1999; 140: 677-680
- Naumann M, Hofmann U, Bergmann I, Hamm H, Toyka KV, Reiners K. Focal hyperhidrosis: effective treatment with intracutaneous botulinum toxin. Arch Dermatol 1998;134:301-4.
- Odderson IR. Hyperhidrosis treated by botulinum A exotoxin. Dermatol Surg 1998;24:1237-41.
- Glogau RG. Botulinum A neurotoxin for axillary hyperhidrosis. Dermatol Surg 1998; 24: 817-819
- Stolman LP. Treatment of hyperhidrosis. Dermatol Clin 1998; 16: 863-869
- Shelley WB, Talanin NY, Shelley ED. Botulinum toxin therapy for palmar hyperhidrosis. J Am Acad Dermatol 1998;38:227-9.
- Naver H, Aquilonius S. The treatment of focal hyperhidrosis with botulinum toxin. Eur J Neurol 1997;4(Suppl):S75-9.
- Schnider P, Binder M, Auff E, Kittler H, Berger T, Wolff K. Double-blind trial of botulinum A toxin for the treatment of focal hyperhidrosis of the palms. Br J Dermatol 1997;136:548-52.
- Lai YT, Yang LH, Chio CC, Chen HH. Complications in patients with palmar hyperhidrosis treated with transthoracic endoscopic sympathectomy. Neurosurgery 1997; 41: 110-113
- Naumann M, Flachenecker P, Brocker EB, Toyka KV, Reiners K. Botulinum toxin for palmar hyperhidrosis [letter]. Lancet 1997;349:252.
- Drott C, Claes G. Hyperhidrosis treated by thoracic sympathectomy. Cardiovasc Surg 1996; 4: 790-791
- Drott C, Gothberg G, Claes G. Endoscopic transthoracic sympathectomy: an efficient and safe method for the treatment of hyperhidrosis. J Am Acad Dermatol 1995; 33: 78-81
- Herbst F, Plas EG, Fugger R, Fritsch A. Endoscopic thoracic sympathectomy for primary hyperhidrosis of the upper limbs: a critical analysis and long-term results of 480 operations. Ann Surg 1994; 220: 86-90
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