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Zyderm/Zyplast :: Formulations
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Zyderm I
Collagen Implant |
Zyderm II
Collagen Implant |
Zyplast
Collagen Implant |
| Composition |
35 mg/ml bovine dermal collagen dispersed in saline containing 0.3% lidocaine. |
65 mg/ml bovine dermal collagen dispersed in saline containing 0.3% lidocaine. |
35 mg/ml bovine collagen cross-linked with glutaraldehyde dispersed in saline containing 0.3% lidocaine. |
| Indication |
Fine lines, wrinkles and shallow scars. Thin-skinned areas. |
Moderate to deep lines, wrinkles and scars. Thicker-skinned areas. |
Deep lines, furrows and scars. |
| Placement in dermis |
Superficially, papillary level. |
Superficially, papillary level. |
Mid to deep, reticular level. |
| Amount of correction |
200% |
150% |
100% |
| Angle of needle while injecting |
10-25 degrees |
10-25 degrees |
45 degrees |
| ANGTM needle exposure length |
1mm |
1mm |
2mm |
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All of these are suspensions of bovine dermal collagen. The only difference between Zyderm I and II is the concentration of collagen (35 mg/cc with Zyderm I and 65 mg/cc with Zyderm II). Zyplast is a somewhat more stable product because it contains collagen cross-linked with 0.0075% glutaraldehyde (35 mg glutaraldehyde cross-linked per cc of collagen), which strengthens the collagen fibers thereby rendering it more resistant to decomposition as a result of the action of host collagenases. All of these products contain lidocaine, which reduces the pain of the injection.
Zyderm:
Zyderm 1 implants are used to treat fine lines, shallow scars, and
thin-skinned areas. Zyderm 2 implants are indicated for moderate
lines, wrinkles, scars, and thicker-skinned areas. Both are administered
by an injection with a fine-gauge needle just beneath the surface of the
skin.
Zyplast:
A form of injectable collagen that is cross-linked with the chemical
glutaraldehyde to strengthen the collagen fibers. It is used to treat
pronounced scars, lines, and furrows, as well as to define the lip border.
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